Gaurav Pandey

I am Gaurav Pandey, Ph.D., a Staff Researcher at the Milk Analytics Core of the Human Milk Institute (HMI) at the University of California San Diego. My research explores the intricate connections between maternal health, human milk composition, and infant development — collectively referred to as the “mother–milk–infant triad." By integrating advanced analytical platforms such as Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and Liquid Chromatography–Mass Spectrometry (LC-MS), I investigate how essential micronutrients, bioactive compounds, and environmental contaminants (exposomes) interact within this triad. My work provides quantitative insights into how maternal exposures and physiology shape the nutritional and protective landscape of human milk, informing strategies to promote healthier beginnings for infants worldwide.

Prior to joining HMI, I was a postdoctoral researcher in the Department of Molecular Medicine at Prof. Mia Huang’s Lab at Scripps Research, where I combined glycoproteomics, protein engineering, and synthetic chemistry to uncover how proteoglycans and glycans regulate cancer and viral infection pathways. My work included defining glycosylation changes in Human Cytomegalovirus (HCMV) infection and providing translational insights for therapeutic antibody glyco-optimization.

Earlier, as a postdoctoral researcher in Prof. Ryan Julian’s Lab at the University of California Riverside, I investigated lysosomal dysfunction in Alzheimer’s disease using advanced mass spectrometry approaches. My studies revealed how spontaneous chemical modifications of long-lived proteins impair proteostasis and drive neurodegeneration, advancing our understanding of the molecular underpinnings of age-related diseases.

I earned my Ph.D. from the Indian Institute of Technology (IIT) Guwahati, where I developed peptide-based therapeutics and non-invasive physical modulators for Alzheimer’s disease. My doctoral work led to innovative therapeutic prototypes and a patented electric-field-based modulation device.

Across my research journey — from neurodegeneration to glycomics to human milk science — I have been driven by a single vision: to uncover how molecular systems maintain health or falter in disease, and to translate those insights into practical, life-improving solutions.

When I am not working, I stay active through sports like badminton and tennis, and I enjoy running and meditation. I love spending time with my family, reading, and learning new things. Lately, I have been exploring my creative side through graphic design.


Research Interests

  • Human Milk Analytics
  • Maternal–Infant Health
  • Micronutrient Profiling
  • Mother–Milk–Infant Triad
  • Mass Spectrometry
  • Proteopathies
  • Self-Assembly
  • Glycomics

  • Education

    Indian Institute of Technology, Guwahati, India

    Ph.D., in Biosciences & Bioengineering
    2013 - 2019

    University of Hyderabad, India

    Master of Technology, in Bioinformatics
    2011 - 2013

    Gautam Buddh Technical University, India

    Bachelor of Technology, in Biotechnology
    2007 - 2011

    Skills

    Computational Biology skills

    Publications

  • Gaurav Pandey, and Ryan R Julian. LC-MS Reveals Isomeric Inhibition of Proteolysis by Lysosomal Cathepsins. Analysis & Sensing, 2022. DOI: 10.1002/anse.202200017
  • Gaurav Pandey, and Debika Datta. Peptide-Based Nanomaterials-Applications and Challenges. Book Chapter in De Novo Peptide Design: Principles and Applications, Elsevier , 2022.
  • Gaurav Pandey, and Vibin Ramakrishnan. Invasive and Non-Invasive Therapies for Alzheimer’s Disease and Other Amyloidosis. Biophysical Reviews, 2020.DOI: 10.1007/s12551-020-00752-y
  • Gaurav Pandey, Sudhir Morla, Sachin Kumar, and Vibin Ramakrishnan. Modulating Aβ Fibrillogenesis with ‘Trojan’ Peptides. Neuropeptides, 2020.DOI: 10.1016/j.npep.2020.102030
  • Gaurav Pandey, Sudhir Morla, Sachin Kumar, and Vibin Ramakrishnan. Modulating Tau Fibrillogenesis with ‘Trojan’ Peptides. Biochimica et Biophysica Acta - General Subjects, 2020. DOI: 10.1016/j.bbagen.2020.129569
  • Gaurav Pandey, Prem Prakash Das, and Vibin Ramakrishnan. Directive effect of chain length in modulating peptide nano-assemblies. Protein and Peptide Letters, 2020. DOI: 10.2174/0929866527666200224114627
  • Jahnu Saikia, Gaurav Pandey, Sajitha Sasidharan, Ferrin Antony, Harshal B. Nemade, Sachin Kumar, Nitin Chaudhary, and Vibin Ramakrishnan. Electric Field Disrupts Amyloid Aggregation; Potential Non-invasive Therapy for Alzheimer's Disease. ACS Chemical Neuroscience, 2019.DOI:10.1021/acschemneuro.8b00490
  • Gaurav Pandey, Sudhir Morla, Harshal B. Nemade, Sachin Kumar and Vibin Ramakrishnan. Modulation of Aggregation with Electric Field; Scientific Roadmap for a Potential Non-Invasive Therapy Against Tauopathies. RSC Advances, 2019. DOI:10.1039/C8RA09993F
  • Gaurav Pandey, and Vibin Ramakrishnan. Modulation of Aggregation with Electric Field; Electric feld assisted inhibition of aggregation in amyloidogenic proteins. Proceedings of the 35th European Peptide Symposium, 2018. DOI:10.17952/35EPS
  • Gaurav Pandey, Jahnu Saikia, Sajitha Sasidharan, Deep C. Joshi, Subhash Thota, Harshal B. Nemade, Nitin Chaudhary, and Vibin Ramakrishnan. Modulation of Peptide Based Nano-Assemblies with Electric and Magnetic Fields. Scientific Reports, 2017.DOI:10.1038/s41598-017-02609-z

  • Patents

    International Patent.
  • Patent No. WO/2019/012556. Dated 17.01.2019.
  • Title: A device treatment of neurodegenerative diseases.
    Patent No. WO/2019/012556

    Indian Patents
  • Patent No. TEMP/E-1/36478/2019-KOL. Dated 27.08.2019.
    Title: Peptide-based modulators of amyloidogenic peptides.

  • Patent No. 243/KOL/2015. Dated 09.03.2015.
    Title: Generation and usage of stimulus responsive nanostructures.

  • Patent No. 10258/2016-KOL. Dated 31.03.2016.
    Title: Magnetic hydrocarbon crystals.


  • Awards & Certifications


    Professional Affiliations

  • American Peptide Society
  • European Peptide Society
  • Korean Peptide Protein Society
  • Boulder Peptide Society
  • The Royal Society of Chemistry (affiliate)
  • American Society of Mass Spectrometry
  • Dutch Society for Mass Spectrometry
  • The Irish Mass Spectrometry Society
  • Indian Biophysical Society
  • Society of Biological Chemists, India
  • Curriculum Vitae