I am a post-doctoral researcher in Prof. Mia Huang’s Lab in Department of Molecular Medicine at Scripps. Here, I am trying to utilize the combined potential of mass spectrometry-based glycoproteomics, protein engineering, and synthetic chemistry to decipher the role of proteoglycans and glycans in a myriad of pathophysiological pathways.
Previously, I was a postdoc in Prof. Ryan Julian’s Lab at UC Riverside, where I investigated the role of spontaneous chemical modification mediated lysosomal dysfunction in triggering neuronal loss and the potential effect of this phenomenon in the cascade of events leading to the disrupted proteostasis, amyloid formation, and tauopathies associated with Alzheimer’s Disease (AD).
Age-related diseases such as Alzheimer’s Disease (AD) at present cannot be prevented, cured, or even slowed. My doctoral research at IIT Guwahati was focused on the design, development, and optimization of cost-effective treatments of this mind-robbing protein aggregation mediated disorder. To achieve this, I employed a hybrid approach of utilizing non-invasive electric fields and structure-based designed peptides as chemical modulators. Our design approach for aggregation modulators has been in silico modeling techniques and molecular dynamics simulations, followed by experimental validation using state of the art biophysical and cell viability assays.
When I am not working, I do a lot of sport. I play badminton and tennis. I run and meditate. I love to spend time with my family. I also enjoy reading, learning about new things. Currently, I am trying my hands on graphic designing.